Ciocoiu Manuela MD, PhD
University of Medicine and Pharmacy “Grigore T. Popa” Iasi
The pathophysiological aspects and therapeutic perspectives of using phenolic compounds in dermatological conditions
Manuela Ciocoiu, Iuliana Hunea, Codruta Badescu
Alopecia, acne vulgaris, fungal infections or cutaneous hyperpigmentations may, nowadays, be treated efficiently with the help of polyphenols. The anti-inflammatory response demonstrated by these decreases the secretion of 1ß-interleukin and the activity of the kB nuclear factor. Some polyphenols have characteristics that are synergic with anticancer chemotherapeutic agents. Therefore, an adequate combined usage of polyphenols and chemotherapy drugs leads to the reduction of side effects without lowering the efficiency rates of the latter. The administration of these has strong anti-angiogenic effects, with a prospective of being able to control overgrowth or to induce tumoral regression. The inhibition of the proliferating cell nuclear antigen (PCNA) inside the tumoral microsystem supports the concept of malignant cell proliferation being supressed by phenolic compounds. Given the requirements of a neutral or more alkaline pH, phenolic compounds suffer structural breakdown, which determines a remarkable increase in the inhibition of the telomerase. An association of polyphenols inhibits more efficiently the tumoral evolution than individually administered constituents, through mechanism involved distinctly in intracellular signaling.