Phar. Docea Anca Oana
University of Medicine and Pharmacy Craiova
Centella asiatica effects in dermatology from traditional use to scientific proofs
Author: Anca Oana Docea
Centella asiatica is a medicinal plant used in traditional medicine as ‘panacea’ for hundreds of years. Its therapeutic properties are determined by the combination of mandecassic acid, asiatic acid, asiaticoside and madecasosside found in the extract. Starting from the knowledge of traditional medicine, in the last years many researchers started to study in vitro and in vivo Centella asiatica extract for its beneficial properties in healing process of wounds, hypertrophic scars and burns. Other studies showed that herbal ointment with Centella asiatica can have a positive effect in the treatment of mild-to moderate atopic dermatitis. Mechanistic approaches showed that Centella asiatica promotes fibroblast proliferation and increase the synthesis of collagen and intracellular fibronectin content and inhibits inflammatory phase of hypertrophic scars. Scientific proofs showed that Centella asiatica extracts are promising candidates for use in different dermatological disorders with minimum side effects.