PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS and FMWAS
Professor and Chairman Department of Toxicology & Forensic Science, Medical School, University of Crete
Real life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine
Author: Aristidis Tsatsakis, PhD, ERT, DSc
Risk assessment for human protection is historically and up to nowadays based on some long-established practices and assumptions for hazard identification and characterisation, such as a) testing in high doses, b) testing only of single chemicals, and c) linear extrapolation to low doses. Though these practices were considered handy and useful for many decades, it is now globally recognised that they are not simulated real life conditions. Real life risk is coming from the exposure to complex mixtures of many different chemicals and their toxicity in mixtures might be altered in relation of their toxicity when studied in isolation. In addition, real life exposure is mainly exposure to low doses. However, the assumption that low dose’s toxicity is covered from experimentation in high doses because all effects are following a linear and monotonic dose-response curve, is seriously challenged through a number ofstudies of the last three decades. As many of the technical drawbacks of the past are nowadays eliminated and new technologies and methodologies are available, we consider that it is time to go ahead with toxicology for Real Life Risk Simulation. As more are known in relation to real life combined exposure, we focus our research in an area with complete lack of data, meaning the low-dose-long-term toxicity testing of complex chemicals’ mixtures that simulates real life exposure. The Toxicology of the 21st century faces with the challenge of explain why from epidemiological studies we found that chemicals in doses consider safety are important factors that lead to the development of different chronic diseases. Precision medicine approach based on metabolome, genome, and microbiome relate data on the effect of toxic exposure to the phenotype. Toxic exposure inflicts damage at metabolic, genetic and microbiome levels, increasing thus cellular turnover, telomere attrition and the rate of aging. Data from our ongoing research in this direction will be presented.
Professor, Academician Aristidis Tsatsakis, PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS and FMWAS is the Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion. Prof Tsatsakis has published well over 1000 works (articles in journals, books and abstracts proceedings), over 500 of them in ISI journals. He is the holder of several patents and has an extensive array of citations (over 11,000 GS) and reads /downloads (over 80,000 RG) of his papers. His current IF index is 50 (GS) and 41 (ISI). Prof Tsatsakis has given over 200 keynote and plenary lectures in international congresses and has been the promoter and chair of numerous Symposiums and workshops in International Forum. He has coordinated as a PI in over 60 scientific research and technology projects and has established worldwide collaborations. Prof. Tsatsakis has a long standing activity as Editor in toxicology journals; he is currently Editor in chief of Toxicology Reports and editor of Food and Chemical Toxicology and has served as editor and guest editor in many other journals, such as Toxicology, Food and Chemical Toxicology, Toxicology Letters. Aristides Tsatsakis was elected EUROTOX President-Elect in 2012 served as President (2014-2016) of the Federation of European Toxicologists and European Societies